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Circumstances OF USE: The data During this databases is intended to supplement, not substitute for, the know-how and judgment of Health care professionals. The knowledge is just not intended to protect all possible utilizes, directions, safeguards, drug interactions or adverse results, nor need to it's construed to indicate that usage of a particular drug is Harmless, proper or helpful for you personally or any individual else.
Promethazine with Codeine Oral Option is indicated for your short-term relief of coughs and higher respiratory signs and symptoms connected with allergy or the common cold in patients eighteen a long time of age and older.
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The narcotic antagonist, naloxone hydrochloride, may very well be administered when substantial respiratory despair takes place with promethazine and codeine; any depressant effects of promethazine are usually not reversed with naloxone. Diazepam may be utilised to regulate convulsions. Avoid analeptics, which may induce convulsions. Acidosis and electrolyte losses ought to be corrected. A rise in temperature or pulmonary issues may signal the need for establishment of antibiotic therapy.
Codeine has become reported to indicate no proof of carcinogenicity or mutagenicity in many different check devices, including the micronucleus and sperm abnormality assays as well as Salmonella assay. Promethazine was nonmutagenic in the Salmonella take a look at website procedure of Ames.
This merchandise may possibly consist of inactive substances, that may trigger allergic reactions or other complications. Talk to your pharmacist For additional aspects.
When offered concomitantly with promethazine, the dose of barbiturates needs to be lowered by at the least one particular-50 %, as well as dose of here narcotics really should be minimized by one particular-quarter to 1-fifty percent. Dosage has to be individualized. Excessive quantities of promethazine HCl relative into a narcotic may well cause restlessness and motor hyperactivity in the patient with agony; these indications generally vanish with enough Charge of the ache.
Opioid medication can connect with many other prescription drugs and cause harmful Uncomfortable side check here effects or Dying. Ensure your doctor is aware get more info if You furthermore mght use:
The results of concomitant use or discontinuation of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with codeine are elaborate.
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Epinephrine – Due to possible for promethazine to reverse epinephrine's vasopressor influence, epinephrine really should not be employed to deal with hypotension linked to promethazine overdose.
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If you're taking promethazine and codeine routinely, have a skipped dose when you consider it. If it is near enough time on your up coming dose, skip the missed dose and return to your regular time.
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